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Tylenol Cold + Flu Severe Night For the temporary relief of the following cold/flu symptoms minor aches and pains headache sore throat nasal congestion cough sinus congestion and pressure sneezing and runny nose. Helps clear nasal passages. Relieves cough to help you sleep. Temporarily reduces fever. Tylenol Cold + Flu Severe Day For the temporary relief of the following cold/flu symptoms minor aches and pains headache sore throat nasal congestion cough. Helps loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive. Temporarily reduces fever.